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Pheniramine Maleate

Method: HPLC
Matrix: Medicine
Application No.: 101969
Componds: Phenylethyl alcohol, Pheniramine maleate
Columns: Diamonsil® Plus C18 5μm 250 x 4.6 mm
Cat No.: 99403
Sample Pretreatment: System suitability solution: dissolve suitable quantities of Pheniramine Maleate and phenylethyl alcohol in water to obtain a solution containing about 0.24 and 3.6 mg per mL, respectively.
Conditions: Mobile phase:
A: Dissolve 1.08 g of sodium 1-octane sulfonate in 1-liter 1.5% (v/v) acetic acid solution, add 5 mL of triethylamine, mix, and filter.
B: Acetonitrile
Isocratic conditions: 78% A / 22% B
Detector: UV 265 nm
Flow rate: 1.0 mL/min
Injection volume: 10 µL
Column temp.: 30 ℃
Keyword: Phenylethyl alcohol, Pheniramine maleate, HPLC, Diamonsil Plus C18
Abstract: Pheniramine Maleate is an antihistamine medication, used commonly to treat allergic conditions. The experimental conditions follow guidelines from the USP43-NF38 monograph method.

 

Peaks

Compound

Retention Time

(min)

RRT

Resolution

Tailing Factor

1

Phenylethyl alcohol

12.017

0.5

-

1.55

2

Pheniramine maleate

24.038

1.0

24.39

1.06