Lab Glassware Division 中文(Chinese)

UHPLC/MS/MS Method for Determination of Molnupiravir, a Promising Treatment for COVID-19

Method: HPLC-MS
Matrix: Medicine
Application No.: 101953
Componds: Molnupiravir
Columns: Navigatorsil 2.7 μm C18, 100 x 2.1 mm
Cat No.: 88003
Sample Pretreatment: Working solution of 0.05 µg/mL was obtained by dilution of the stock solution with acetonitrile/water (1/9, v/v). Standard solutions should be stored at 4 ℃.
Conditions: Mobile Phase:
A: 0.1% formic acid in water;
B: 0.1% formic acid in acetonitrile
Scan mode: ESI+
Flow Rate: 0.3 mL/min
Injection: 2 µL
Temperature: 22 ℃
Publisher: Dikma Technologies Inc.
Keyword: UHPLC/MS/MS, Molnupiravir, Navigatorsil 2.7 µm C18
Abstract: UHPLC/MS/MS Method provide simple and rapid determination of molnupiravir and can be easily applied to drug development and clinical trial studies of this promising treatment.

 

Compounds

Concentration (µg/mL)

Retention Time(min)

MS→MS1 Ions

(Precursor→Product 1)

MS→MS2 Ions

(Precursor→Product 2)

Molnupiravir

0.05

3.28

330.2 → 128.2

330.2 → 82.1